Preface (C. Romanin, W. F. Graier, K. Groschner) -- SECTION 1: SOCE - Fundamental mechanistic concepts -- Introduction (J. W. Putney) -- 1.1 The STIM-Orai pathway -- Structural insights into Ca2+ sensing by stromal interaction molecules (P. B. Stathopulos, M. Ikura) -- 1.2 The STIM-Orai pathway. Orai, the pore-forming subunit of the CRAC channel (P. G. Hogan) -- 1.3 The STIM-Orai pathway. The interactions between STIM and Orai (R. Schindl, M. Fahrner, M. Muik, I. Derler, C. Romanin) -- 1.4 STIM-TRP pathways. The STIM1/Orai/TRPC channels multiple Ca2+ influx complexes (J. H. Hong, M. S. Kim, K. P. Lee, J. P. Yuan, S. Muallem) -- 1.5 STIM-TRP pathways. Function and regulation of TRPC1: Contribution to Ca2+ entry activated by store depletion (I. S. Ambudkar, K. T. Cheng, H. L. Ong, X. Liu) -- 1.6 Microdomain organization and the role of second messengers. Microdomain organization of SOCE signaling (C. Moreno, L. Vaca) -- 1.7 Microdomain organization and the role of second messengers. Store-operated Ca2+ entry: Endogenous messengers and mediators (V. M. Bolotina) -- SECTION 2: SOCE - Crosstalk between organelle and cellular compartments -- Introduction: Ca2+ signaling and gene regulation: An introduction (A. B. Parekh) -- 2.1 New aspects of the contribut ion of ER to SOCE regulation. The role of the ER and ER-plasma membrane junctions in the regulation of SOCE (H. Dingsdale, L. Haynes, G. Lur, A. Tepikin) -- 2.2 New aspects of the contribution of ER to SOCE regulation. The contribution of SERCA to the regulation of SOCE (J. García-Sancho, M. T. Alonso) -- 2.3 New aspects of the contribution of ER to SOCE regulation. TRPC proteins as a link between plasma membrane ion transport and intracellular Ca2+ stores (A. Bavencoffe, M. X. Zhu) -- 2.4 The role of mitochondria in the activation/maintenance of SOCE. Store-operated Ca2+ entry and mitochondria (A. Spät, G. Szanda) -- 2.5 The role of mitochondria in the activation/maintenance of SOCE. Local regulation of plasma membrane channels by mitochondria (N. Demaurex, M. Frieden) -- 2.6 The role of mitochondria in the activation/maintenance of SOCE. The contribution of distinct mitochondrial Ca2+ uptake mechanisms, mitochondrial motility and location to store-operated Ca2+ entry (R. Malli, W. F. Graier) -- 2.7 Tissue specificity. The role of nanospaces between the organellar membranes in smooth muscle Ca2+ signaling (N. Fameli, A. M. Evans, C. van Breemen) -- 2.8 Tissue specificity. SOCE - implications for Ca2+ handling in endothelial cells (L. A. Blatter) -- SECTION 3: SOCE - Molecular and cellular (patho)physiology -- Introduction (J. A. Rosado) -- 3.1 Immune system. SOCE mediated by STIM and Orai genes in immune function and disease (S. Feske) -- 3.2: Cardiovascular system. STIM1/Orai1-mediated store-operated Ca2+ entry in cardiovascular disease (R. K. Motiani, M. Trebak) -- 3.3: Cardiovascular system. TRPC/Orai-containing channels, Na+/Ca2+ + exchanger and Ca2+ handling in hypertension (V. A. Golovina) -- 3.4: Cardiovascular system. SOCE and TRPC/STIM/Orai signaling in cardiac myocytes (H. Watanabe, T. Ohba, H. Ito) -- 3.5: Cardiovascular system. SOCE as a determinant of cardiac pacemaker activity (D.G. Allen, Y. K. Ju, J. Liu, M. S. Imtiaz) -- 3.6: Cardiovascular system. SOCE and Ca2+ handling in platelet dysfunction (J. J. Lopez, G. M. Salido, J. A. Rosado) -- 3.7: Cardiovascular system. Store-operated Ca2+ entry in endothelial pathophysiology (K. Groschner, M. Poteser) -- 3.8: Nervous system. Pathophysiological perspective of neuronal store-operated Ca2+ signaling (S. Bollimuntha, B. Pani, B. B. Singh) -- 3.9: Skeletal muscle. Store-operated Ca2+ entry and STIM/Orai signaling in skeletal muscle (J. A. Stiber, P. B. Rosenberg) -- 3.10: Skeletal muscle. Store-operated channels and Ca2+ handling in muscular dystrophy (U. T. Ruegg, G. Shapovalov, K. Jacobson, J. Reutenauer-Patte, H. Ismail, O. M. Dorchies, P. Avdonin) -- 3.11: Reproductive system. Store-operated Ca2+ entry in germ cells - role in egg activation (Z. Machaty, C. Wang, K. Lee).