Disability and Inequality explores the lived experiences of persons with disabilities (PWDs) in Jamaica. It examines measurable socioeconomic inequalities within the marginalized sociocultural disability identity, which induce inferior education, training, and labor market outcomes compared to persons without disabilities. The author provides an evidence-based, theoretically grounded, and implementable public policy framework, called Framework of Key Determinants for Political and Socioeconomic Inclusion of PWDs, which advances anti-discrimination legislation and a twin-track policy schema with interconnected enablers of human rights. Using this framework, Jamaica, the Caribbean, and other Southern countries looking for strategies to fulfill commitments set out by the United Nations' Convention on the Rights of Persons with Disabilities will find approaches to sustain existing progress, and address structural systemic inequalities which continue to deny PWDs long-term sustainable development.