Mammalian Preimplantation Development
Title:
Mammalian Preimplantation Development
ISBN:
9780128016176
Publication Information New:
Cambridge, MA : Academic Press is an imprint of Elsevier, 2016.
Physical Description:
1 online resource (xxi, 455 pages, 32 unnumbered pages of plates : illustrations (chiefly color)).
Series:
Current topics in developmental biology ; volume 120
Current topics in developmental biology ; v. 120.
General Note:
Includes index.
Contents:
Front Cover; Mammalian Preimplantation Development; Copyright; Contents; Contributors; Preface; 1. The Foundation of Mammalian Development; 2. The Unique Goals of Preimplantation Development; 3. The Events in Preimplantation and Peri-Implantation Development; 4. Recent Advances; 5. The Future of Preimplantation Development; 5.1. Genetic Diagnosis; 5.2. Genetic Intervention; 6. Cancer Stem Cells; References; Chapter One: Regulation of the Embryonic Cell Cycle During Mammalian Preimplantation Development; 1. Introduction; 1.1. The Somatic Cell Cycle; 2. The Preimplantation Cell Cycle.
2.1. Preparation for the First Cell Cycle2.2. Initial Embryonic Cell Cycles; 2.3. Maternal-Zygotic Transition, Genome Activation, and Epigenetic Reprogramming; 2.4. Blastocyst Formation and Compaction; 2.5. Late Preimplantation; 3. Regulation of the Preimplantation Cell Cycle; 3.1. Cdks and Cyclins; 3.2. Cellular Regulation of Cdk/Cyclin Complexes; 4. Mouse Models of Cell Cycle Regulators as Developmental Tools; 4.1. Cell Cycle-Related Cdk/Cyclin Complexes; 4.1.1. Cdk4/Cdk6; 4.1.2. D-Type Cyclins; 4.1.3. Cdk2; 4.1.4. The E-Type Cyclins; 4.1.5. The A-Type Cyclins; 4.1.6. Cdk1.
4.1.7. B-Type Cyclins4.1.8. Summary of Cell Cycle-Driving Cdks/Cyclins; 4.1.9. Cdk-Activating Kinase; 4.2. The Retinoblastoma and Related Pocket Proteins; 4.3. The E2F Family as a Downstream Target of Cdk/Cyclin Complexes; 4.4. Cdk3/Cyclin C; 4.5. Cdks and Transcription; 4.5.1. Cdk7/Cyclin H and Cdk9/Cyclin T; 4.5.2. Cdk8/Cyclin C; 5. DNA Damage and Checkpoint Signaling in the Preimplantation Embryo; 5.1. G1/S Checkpoint; 5.1.1. Embryonic Dependence on Cell Cycle Checkpoint Proteins; 5.1.2. ATR; 5.1.3. ATM; 5.1.4. Chk1/2; 5.2. Effectors of the G2/M Checkpoint; 5.2.1. The Cdc25 Phosphatases.
5.2.2. Wee1/Myt1 Kinases5.2.3. Polo-Like Kinase 1; 5.3. The Spindle Assembly Checkpoint; 5.3.1. Emi1; 6. Concluding Remarks; References; Chapter Two: Genome Duplication at the Beginning of Mammalian Development; 1. Basic Concepts; 1.1. Genome Duplication Is a Problem of Astronomical Proportions; 1.2. All Living Organisms Use the Replication Fork Paradigm; 1.3. Nuclear DNA Replication Begins in the Zygote; 1.4. The Same Replication Machinery Is Used from Zygote to Adult; 1.5. Not All Replication Origins Are Replicators; 2. Replication Origins Are Established in Two Steps.
2.1. Prereplication Complex Assembly (Origin Licensing)2.2. Preinitiation Complex Assembly (Origin Activation); 3. The First Mitotic Cell Division Is Universal; 4. The Second Cell Division Distinguishes Mammals from Nonmammals; 4.1. Cell Cleavage Gives Way to Cell Growth; 4.2. Cell Cycle Checkpoints Are Acquired at Different Stages in Development; 4.3. DNA Methylation Patterns Inherited from Gametes Are Erased; 4.4. Activation of ZGE Does Not Depend on DNA Replication; 5. Replication Origins Are Developmentally Regulated; 5.1. The "Jesuit Model" for Origin Selection.
Abstract:
This volume covers mammalian preimplantation development, and includes contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as cell proliferation, cell differentiation, and biological significance. Mammalian Preimplantation Development, the latest volume in the Current Topics in Developmental Biology series covers mammalian preimplantation development, and includes contributions from an international board of authors. The book's chapters provide a comprehensive set of reviews covering such topics as cell proliferation, cell differentiation, and biological significance.
Local Note:
Elsevier
Added Author:
Electronic Access:
Full Text Available From Elsevier e-Books
Language:
English