Cell Fate in Mammalian Development
Title:
Cell Fate in Mammalian Development
ISBN:
9780128043356
9780128042526
Edition:
First edition.
Publication Information New:
Cambridge, MA : Academic Press, an imprint of Elsevier, 2018.
Physical Description:
1 online resource (xiii, 390 pages : illustrations
Series:
Current topics in developmental biology ; v. 128
Current topics in developmental biology ; v. 128.
Contents:
Front Cover; Cell Fate in Mammalian Development; Copyright; Contents; Contributors; Chapter One: Introduction; Chapter Two: Cell Polarity-Dependent Regulation of Cell Allocation and the First Lineage Specification in the Preimplanta ... ; 1. Introduction; 1.1. Models for Early Lineage Specification in the Preimplantation Mouse Embryo; 1.1.1. The Inside-Outside Model; 1.1.2. The Cell Polarity Model; 2. Compaction and Polarization: Two Key Morphogenetic Events Influencing the Formation of Outer/Inner Cells
3. Asymmetric Division and the Establishment of the Outer/Inner Configuration of Polar/Apolar Cells4. Activation of Lineage-Specific Genetic Programs in the Outer/Inner Cells to Form the TE and ICM Lineages; 5. How Do the Cells Within the Embryo Sense Their Position to Properly Regulate Hippo Signaling?; 6. Future Perspectives; Acknowledgments; References; Further Reading; Chapter Three: Cell Fate Decisions During Preimplantation Mammalian Development; 1. Introduction; 2. Gene Knockouts Pave the Way to Understand Cell Fate Decisions; 3. Different Patterns of TF Expression Levels
4. Gene Expression Dynamics5. TF Intracellular Transport Dynamics; 6. TF Nuclear-Cytoplasmic Shuttling in Embryos; 7. Cell-to-Cell Variability in the Early Embryo; 8. TF-DNA Binding Dynamics in the Embryo; 9. Epigenetic Regulation; 10. Additional Levels of Gene Regulation; 11. How Gene Regulation Impacts on Cell Shape and Position; Acknowledgments; References; Chapter Four: Our First Choice: Cellular and Genetic Underpinnings of Trophectoderm Identity and Differentiation in the M ... ; 1. Heterogeneity Emergence in the Mouse Embryo; 2. The TE Gene Regulatory Network
3. Establishment of TE Fate4. Plasticity During Lineage Segregation; 5. Recapitulating TE Identity in Culture; 6. TE Derivatives and Their Role in the Postimplantation Embryo; 7. Conclusions; Acknowledgments; References; Chapter Five: Primitive Endoderm Differentiation: From Specification to Epithelialization; 1. Introduction; 2. Generation of Trophectoderm and Inner Cell Mass Cell Lineages; 3. Regulation of the Epi/PrE Specification; 4. Mechanism for Salt and Pepper Pattern Propagation; 5. Induction of Epi/PrE Specification; 6. PrE Maturation Through the FGF Pathway
7. Other Signaling Pathways Involved in PrE Maturation and Maintenance8. Cell Sorting and PrE Epithelialization at the Late Blastocyst Stage; 9. The PrE Derivatives: The Visceral and the Parietal Endoderm; 10. Conclusion; References; Chapter Six: The Regulative Nature of Mammalian Embryos; 1. Introduction; 2. Blastomere Potency to Give Rise to the Whole Organism; 2.1. Compensation for the Loss: Embryo Splitting as a Proof of Totipotency and Plasticity of Blastomeres; 2.2. Monozygotic Multiplets: Proof of Totipotency of Blastomeres in Nature
Abstract:
Cell Fate in Mammalian Development, Volume 128, the latest release in the Current Topics in Developmental Biology series, provides reviews on cell fate in mammalian development. Each chapter is written by an international board of authors, with this release including sections on the Specification of extra-embryonic lineages during mouse pre-implantation development, Cell polarity and fate specification, The circuitry that drives trophectoderm identity, Breaking symmetry and the dynamics of transcription factors directing cell fate specification, Mechanics and cell fate, How physical properties of cells change in development and their effect on cell fate decisions, and more. Provides the authority and expertise of leading contributors from an international board of authorsIncludes new sections on the specification of extra-embryonic lineages during mouse pre-implantation development, cell polarity and fate specification, the circuitry that drives trophectoderm identity, and morePresents the latest release in the Current Topics in Developmental Biology series
Local Note:
Elsevier
Subject Term:
Electronic Access:
Full Text Available From Elsevier e-Books
Language:
English