Advances in Biomembranes and Lipid Self-Assembly. Volume 27
Title:
Advances in Biomembranes and Lipid Self-Assembly. Volume 27
ISBN:
9780128157732
Publication Information New:
San Diego : Elsevier Science, 2018.
Physical Description:
1 online resource (264 pages)
Series:
Advances in Biomembranes and Lipid Self-Assembly ; Volume 27
General Note:
Chapter Four: How Can Artificial Lipid Models Mimic the Complexity of Molecule-Membrane Interactions?
Contents:
Front Cover; Advances in Biomembranes and Lipid Self-Assembly; Copyright; Contents; Contributors; Preface; Chapter One: The Role of Self-Assembling Lipid Molecules in Vaccination; 1. Introduction; 2. Immune Response to Lipids; 2.1. Innate Immune Response to Lipids; 2.2. Lipid-Stimulated PRRs (TLR4); 2.3. TLR4 Signaling; 3. Lipids, Lipid Derivatives, and Lipid Mimetics as Vaccine Adjuvants; 3.1. TLR4-Directed Vaccine Adjuvants Beyond Lipid A; 3.2. Lipid A Derivatives as Vaccine Adjuvants; 3.3. Small Molecule TLR4 Adjuvants; 3.4. Challenges With Animal Models for TLR4 Adjuvant Development.
4. Lipid-Based Self-Assembling Vesicle as Vaccine Platforms4.1. Lipid-Based Nanovesicles as Vaccine Platforms; 4.2. Liposomes as Vaccine Platforms; 4.3. Liposome Antigens and Adjuvants; 4.4. VLPs-Based Vaccines; 4.4.1. Icosahedral and Spherical VLPs; 4.4.2. Filamentous VLPs; 4.5. Utilizing VLPs in the Context of a Highly Pathogenic Virus Research; 4.5.1. Entry; 4.5.2. Budding; References; Further Reading; Chapter Two: The Role of Mitochondrial Outer Membrane Permeabilization (MOMP) in Apoptosis: Studying Bax Pores by Cryo-El ... ; 1. Introduction; 2. In Vitro Reconstitution of MOMP (Fig. 1).
2.1. Outer Membrane Vesicles2.2. Liposomes; 3. Bax Pores Revealed in Liposomes and OMVs by Cryo-Electron Microscopy; 3.1. Freezing Optimization; 3.2. Bax Pores in Liposomes; 3.3. Bax Pores in OMVs; 4. Bax Localization in the Pore; 4.1. Direct and Indirect Labeling of Bax With Nanogold; 4.1.1. Direct Labeling of Bax; 4.1.2. Indirect Labeling of Bax; 4.2. Bax Localization on the Pore Edges; 4.3. Bax Pores in Apoptotic Mitochondria; 5. Possible Pore Formation Mechanisms; 5.1. Bax/Bak Dimer/Oligomer Formation During MOMP; 5.2. Role for a Single Bax Molecule in Pore Formation?
5.3. Membrane Permeabilization Induced by Antimicrobial Peptides6. Summary and Future Directions; Acknowledgments; References; Chapter Three: Electrochemical Biosensor Based on TiO2 Nanomaterials for Cancer Diagnostics; 1. Introduction; 2. Cancer; 2.1. Pathology; 2.2. Cancer Diagnostic: Current Issues; 3. Toward Novel Methods of Cancer Diagnosis; 3.1. Biosensor; 3.1.1. Molecular Recognition Element in Biosensor; 3.1.2. Transducers in Biosensor; 3.2. Electrochemical Biosensor and Electrochemical Detection Techniques; 3.2.1. Voltammetric/Amperometric Biosensors; 3.2.2. Impedimetric Biosensors.
3.2.3. Conductometric and Capacitive Biosensors3.2.4. Potentiometric Biosensors; 3.2.5. Field Effect Transistor (FET)-Based Biosensors; 4. Nanosized Materials; 4.1. TiO2 Nanomaterials in Biomedicine; 4.2. Important Characteristics of TiO2 Nanomaterials for Biosensor Applications; 4.2.1. Specific Surface Area; 4.2.2. Wettability; 4.3. Interactions TiO2 Nanomaterials: Biological Material; 4.3.1. Effect of Gaseous Plasma Surface Treatment; 4.3.2. Effect of Electron Transfer Rate; 5. TiO2 Biosensors; 5.1. TiO2 Biosensors for Human Cancer Detection; 6. Conclusions; References; Further Reading.
Abstract:
Annotation Advances in Biomembranes and Lipid Self-Assembly, Volume 27, formerly titled Advances in Planar Lipid Bilayers and Liposomes, provides a global platform for a broad community of experimental and theoretical researchers studying cell membranes, lipid model membranes, and lipid self-assemblies from the micro- to the nanoscale. The assortment of chapters in this volume represents both original research and comprehensive reviews written by world leading experts and young researchers, with topics of note in this release including TiO2 Nanomaterials as Electrochemical Biosensors for Cancer, the Reconstitution of Ion Channels in Planar Lipid Bilayers: New Approaches, and Shear-Induced Lamellar/Onion Transition in Surfactant Systems.Surveys recent theoretical and experimental results on lipid micro- and nanostructuresPresents potential uses of applications, like clinically relevant diagnostic and therapeutic procedures, biotechnology, pharmaceutical engineering and food productsIncludes both original research and comprehensive reviews written by world leading experts and young researchersProvides a global platform for a broad community of experimental and theoretical researchers studying cell membranes, lipid model membranes and lipid self-assemblies, from micro to nanoscale.
Local Note:
Elsevier
Electronic Access:
Full Text Available From Elsevier e-Books
Language:
English