Wes is 25 years old and is a disaffected, clock-punching drone. His boss chews him out hourly, his girlfriend ignores him routinely, and his life plods on in interminable boredom and routine. Everyone knows Wes will amount to nothing - that is until he meets the sexy woman named Fox, and then everything changes. Wes' estranged father is murdered, and the deadly Fox recruits him into The Fraternity, a secret society that trains him to avenge his father's death, by unlocking his dormant powers. Fox teaches Wes how to develop his lightning-quick reflexes and phenomenal agility. He discovers that The Fraternity lives by an ancient, unbreakable code: to carry out the death orders given by emotionless Fate itself.

Babası öldürülen Wesley Gibson'a (James McAvoy), babasının intikamını alma fırsatı teklif edilir. Kötü adamları yok eden bir suikastçi olarak ünlenen babası bir suikaste kurban gitmiştir. Babasının bıraktığı yerden yola devam etmeye kararlı olan Gibson, babasının ortağı Sloan'dan (Morgan Freeman) eğitim almaya başlar.