Part I. Introduction and Background -- Introduction: Starting the Journey to a Sustainable Ecosystem and Healthy People -- The Bay and Its Watershed: A Voyage Back in Time -- Scientific Concepts for Understanding the health of the Chesapeake Bay and its people -- Part II. Foundations of the Chesapeake Bay Food System and the Consequences of Over-Extraction -- The Algonquin Food System and how it Shaped the Ecosystem and Interactions with the English Colonists of the Chesapeake Bay -- A Fishing Trip: Exploiting and managing the commons of the Chesapeake Bay -- Menhaden, the Inedible Fish that Most Everyone Eats -- Blue Crabs: Beautiful Savory Swimmers of the Chesapeake Bay -- The Chesapeake Bay Oyster: Cobblestone to Keystone -- Passenger Pigeon and Waterfowl: Flights to Extinction and Not -- Part III. Industrial-chemical Agriculture Reshapes the Bay's Ecosystem -- The journey from Peruvian Guano to Artificial Fertilizer ends with too Much Nitrogen in the Chesapeake Bay -- Pesticides bring the War on Nature to The Chesapeake Bay -- Livestock and Poultry: the Other Colonists who Changed the Food System of the Chesapeake Bay -- Part IV. Consequences of and Alternatives to the Standard American Diet: Human and Ecosystem Health -- Instead of Eating Fish: the Health Consequences of Eating Seafood from the Chesapeake Bay Compared to Other Choices -- Sugar Twice Enslaves: Consequences for the People of the Chesapeake -- Eutrophication: Obesity of the Bay and its People -- Finishing the Journey: Urine and Feces as Misplaced Resources -- Plastic Food System Waste Travels Far but Never Goes Away -- Part V. Looking to the Future: Ecology, Economics, Ethics, and Policy for Restoring the Health of the Bay and its People -- A New Food System for The Chesapeake Bay Region and a Changing Climate -- An Organic-Based Food System: A Voyage Back and Forward in Time -- What Nature, Politics and Policy Demand of the Chesapeake Bay and its Food System -- Ethics and Economics of Building a Food System to Recover the Health of the Chesapeake Bay and its People.