Anatomy and physiology of lymphatic circulation -- Pathophysiology of lymphatic circulation in different disease conditions -- Methodological aspects of lymphoscintigraphy: radiopharmaceuticals and instrumentation -- Lymphoscintigraphy for the differential diagnosis of peripheral edemas -- Lymphoscintigraphy for the characterization of intracavitary lymph effusions -- The sentinel lymph node concept in oncologic surgery -- General concepts on radioguided sentinel lymph node biopsy: preoperative imaging, intraoperative gamma-probe guidance, intraoperative imaging, multimodality imaging -- SPECT/CT image generation and criteria of interpretation for sentinel lymph node mapping -- Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in breast cancer -- Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in cutaneous melanoma -- Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in head and neck cancers -- Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in non-small-cell lung cancer -- Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in cancers of the gastrointestinal tract -- Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in cancers of the female reproductive system -- Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in cancers of the male reproductive system -- Preoperative and intraoperative lymphatic mapping for radioguided sentinel node biopsy in kidney and bladder cancers.