I Epidemiology and Statistics -- 1 Epidemiology, statistics and health burden -- 2 PreHypertension, the risk of Hypertension and events -- 3 Parental history of hypertension as the determinant of cardiovascular function -- 4 High normal blood pressure in children and adolescents -- II Pathophysiology of prehypertension.­- Part 1 Alteration of Cardiovascular control systems -- 5 Tachycardia in PreHypertension -- 6 Endothelial dysfunction in early phases of hypertension -- 7 Prehypertension and the Renin angiotensin aldosterone system -- 8 The role of the brain in neurogenic prehypertension -- 9 The blood pressure seeking property of the brain -- Part 2 Organ damage in Prehypertension -- 10 Microvascular structural alternations and tissue perfusion in hypertension and diabetes.-11 The heart in prehypertension -- 12 The role of the kidney in PreHypertension -- 13 Obesity, Hypertension and Chronic Kidney Disease: A Forty Year Retrospective -- 14 Pre-CKD? Early markers of renal dysfunction in patients with Prehypertension -- 15 Arterial stiffness in early phases of Prehypertension -- 16 The role of perivascular fat in raising blood pressure in obesity and diabetes -- 17 The Brain -- 18 Diurnal and pulsatile hemodynamics in individuals with PreHypertension -- 19 Systolic hypertension in youth -- 20 Prehypertension and ethnicity: Haemodynamic mechanisms in young adults -- 21 Hemodynamics (systemic and renal) in prehypertension -- 22 Central blood pressure and Prehypertension -- Section 3: Risk assessment in PreHypertension -- 23 Blood pressure measurement, white coat and masked hypertension.-24 Vascular functional and structural risk assessment in prehypertension -- 25 Blood pressure variability -- 26 Morning Surge of Blood Pressure -- 27 Role of ambulatory Blood Pressure Monitoring in Prehypertension -- 28 Home blood pressure, prehypertension and hypertension -- 29 Blood pressure and atherosclerosis- subclinical arteriosclerosis as an early sign of organ damage -- 30 Response to stress, effort and cold pressor test as predictors of Prehypertension -- 31 Physical Activity and Exercise Training as Important Modifiers of Vascular Health -- 32 Prehypertension and associated metabolic risk factors -- IV End organ damage in PreHypertension -- 33 Early cardiovascular dysfunction in Prehypertension -- 34 Effect of blood pressure lowering in hypertensive rats -- V Clinical studies in PreHypertension -- 35 Review of "old and new studies" in the treatment of PreHypertension -- 36 The CHINON study- argument for early treatment of PreHypertension. Effect of age on progression of hypertension -- 37 The PREVER study -- 38 The TROPHY study -- VI Management of PreHypertension -- 39 Non-pharmacologic approaches for the management of prehypertension -- 40 Antihypertensive drugs and vascular health -- 41 Prehypertension: a case in favor of early use of diuretics -- 42 Treatment of High normal blood pressure in the guidelines -- VII Tentative additional chapters -- 43 History of prehypertension: a saga of misunderstanding and neglect -- 44 Management of Prehypertension and hypertension in women of reproductive age.