This two-volume set presents selected and revised papers from the 10th International Conference of Production Research - Americas, ICPR-Americas 2020, held in Bahía Blanca, Argentina, in December 2020. Due to the COVID-19 pandemic the conference was held in a fully virtual format. The 41 full papers and 11 short papers were thoroughly reviewed and selected from 275 submissions. They are organized in topical sections on optimization; metaheuristics and algorithms; industry 4.0 and cyber-physical systems; smart city; intelligent systems and decision sciences; simulation; machine learning and big data.