Contributors -- I Pathogenesis of Affective Disorders and Basic Mechanisms of Drug Action -- I.A. Animal Models and Antidepressant Predictability -- I.B. Monoamines and Neuropeptides -- I.C. Cholinergic Mechanisms -- I.D. Basic Mechanisms of Antidepressants and Anxiolytics -- I.E. Basic Mechanisms of Lithium Action -- I.F. Monoamine Oxidase Inhibitors -- II Neurobiology of Affective Disorders -- II. A. New Genetic Findings -- II.B. Biological Markers -- II.C. Chronobiology -- II.D. Psychoneuroendocrinology -- III Affective Disorders in Populations at Risk -- III.A. Affective Disorders and Suicide -- III.B. Affective Disorders During Childhood and Adolescence -- III.C. Affective Disorders in the Elderly -- III.D. Affective Disorders and Reproductive Cyclicity in Women -- IV Related Affective Syndromes -- IV.A. Anxiety Disorders -- IV.B. Obsessive Compulsive Disorder -- IV.C. Posttraumatic Stress Disorder -- IV.D. Anorexia and Bulimia -- IV.E. Schizoaffective Disorder -- V New Directions in Treatment -- V.A. Classification and Pharmacotherapy -- V.B. Anticonvulsants in Affective Disorder -- V.C. Treatment Strategies for Resistant Depression -- V.D. Antidepressants in Clinical Practice: Placebo Response in Depression -- V.D. Antidepressants in Clinical Practice: Plasma Levels of Antidepressants -- V.D. Antidepressants in Clinical Practice: Adverse Effects of Antidepressants -- V.E. GABA-Mimetics as Antidpressants -- V.F. Therapeutic Variations in ECT Administration -- V.G. Psychotherapy of Depression.