Natural variation and clocks

Título:

ISBN:

9780128118122

Edición:

First edition.

PRODUCTION_INFO:

Cambridge, MA : Academic Press, 2017.

Descripción física:

1 online resource

Serie:

Advances in genetics ; v. 99

Advances in genetics ; v. 99.

Contenido:

Front Cover -- Natural Variation and Clocks -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Natural Variation of the Circadian Clock in Neurospora -- 1. Introduction -- 2. Neurospora in Nature -- 2.1. The Genus of Neurospora -- 2.2. Natural Habitats -- 2.3. Collection of Neurospora Ecotypes -- 2.4. Neurospora as a Model for Clock Variation Studies -- 3. The Circadian Clock of Neurospora -- 3.1. FRQ-Dependent Oscillators -- 3.1.1. Simple and Coupled Loops -- 3.1.1.1. Positive Regulation of WC-1 -- 3.1.1.2. Coupled Loops in WCC

3.1.1.3. Negative Regulation of FRQ3.1.2. Interlocked Loops in WCC/FRQ -- 3.1.2.1. Negative Feedback Loop -- 3.1.2.2. Positive Feedback Loop -- 3.1.3. Posttranslational Modification of WCC and FFC -- 3.1.4. Negative Feedback Loop in WCC/FRQ/VVD -- 3.2. FRQ-Independent Oscillators -- 4. Natural Variation and the Circadian Clock -- 4.1. Natural Variation in Neurospora Ecotypes -- 4.2. Natural Variation of Core Clock Genes -- 4.3. Technical Challenges for Studying Clock Variation in Neurospora Natural Populations -- 4.4. Methods for Clock Variation Studies

4.4.1. QTL Analysis on Clock Phenotypes4.4.2. Circadian Clocks in Natural Substrates and Natural Environment -- 5. Future Challenges -- 6. Concluding Remarks -- Acknowledgments -- References -- Chapter Two: Natural Variation and Genetics of Photoperiodism in Wyeomyia smithii -- 1. Introduction -- 1.1. Raison dâ#x80;#x99;Ã®tre of Photoperiodism -- 1.2. Geographic Clines -- 1.3. Photoperiodism in Wyeomyia smithii -- 1.3.1. Photoperiodism and Phylogeography -- 1.3.2. Geography of Photoperiodic Response -- 2. Genetics of Photoperiodic Response

2.1. Genetic Potential to Respond to Selection2.2. Hidden Genetic Variation -- 2.2.1. Genotype by Environment Interaction -- 2.2.2. Dominance and Epistasis -- 2.3. Mapping Genotype to Phenotype -- 2.4. Lessons From Quantitative Genetic Approaches in Wyeomyia smithii -- 3. Photoperiodism and Climate Change -- 4. Photoperiodism and Circadian Rhythmicity -- 4.1. Functionality, Definitions, and the Evolutionary Perspective -- 4.2. Daily vs Seasonal Timing -- 4.2.1. BÃơnningâ#x80;#x99;s Proposition Then and Subsequently -- 4.2.2. How W. smithii Assesses Day Length

4.2.3. Resonance4.3. Molecular Connections and Pleiotropy -- 5. Conclusions -- Acknowledgments -- References -- Chapter Three: Natural Variation in Human Clocks -- 1. Introduction -- 2. Direct Measurement of Human Period -- 3. Proxies of Human Period -- 4. Extremes of Human Circadian Period -- 5. Genetic Control of Circadian Rhythms in Mammals -- 6. Genetic Studies of Circadian Rhythm Sleep Disorders -- 7. Genetic Associations With Measured Behavioral Rhythms -- 8. Single-Gene Association Studies of Questionnaire-Determined Human Chronotype

Síntesis:

Natural Variances and Clocks provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs and advances. This updated release includes chapters on a variety of new research, including the Natural variation of the circadian clock in Neurospora, Natural variation and genetics of the photoperiodic timer in the pitcher-plant mosquito, Natural variation in human clocks, and Natural variation in the circadian clock genes in Drosophila and other insects. This series continually publishes important reviews that are ideal for geneticists and their colleagues in affiliated disciplines, critically analyzing future directions. Critically analyzes future directions for the study of clinical genetics. Written and edited by recognized leaders in the field.

Nota local:

Elsevier

Término de la materia:

Genetics -- Research.