Front Cover; Myogenesis in Development and Disease; Copyright; Contents; Contributors; Preface; Chapter One: "What Did Maxwell's Equations Really Have to Do With Edison's Invention?": Addressing the Complexity; 1. Introduction; 2. The Innovation System Pipeline Leading to Clinical Intervention Creation; 3. The Relevance of Health Economics and Population Health in Decision-Making and the Complexity of a Degenerating Muscle; 4. The Price of Failure; 5. Concluding Comments; References; Further Reading; Chapter Two: The Muscle Stem Cell Niche in Health and Disease; 1. Introduction.

2. The Perinatal MuSC Niche3. The Quiescent MuSC Niche; 4. The Regenerative MuSC Niche; 4.1. The Inflammatory Niche; 4.2. The Mitogenic Niche; 4.3. The Differentiative Niche; 5. The MuSC Niche in Aging; 6. The Pathologic MuSC Niche; 7. Targeting the Niche for Therapy; 8. Concluding Remarks; References; Chapter Three: Translational Control of the Myogenic Program in Developing, Regenerating, and Diseased Skeletal Muscle; 1. Introduction; 1.1. Regulation of Translation; 1.2. Myogenesis; 1.2.1. Cell Fate Choices by Multipotent Progenitors.

1.2.2. Multiple Sequential Steps Define the Myogenic Program1.2.3. Establishment of the Muscle Stem Cell Pool; 2. MicroRNA Regulation of the Myogenic Program; 2.1. MicroRNA Regulation of Embryonic Myogenesis; 2.1.1. Dicer Mutants; 2.1.2. MicroRNA Regulation of Myogenic Determination; 2.1.3. MyomiRs; 2.2. MicroRNA Regulation of Quiescent Satellite Cells; 2.3. Intronic MicroRNAs Enforce the Activity of Host Genes Throughout Myogenesis; 2.4. MicroRNA Dysregulation in Muscle Disease; 2.5. Regulation of MicroRNA Activity With Long Noncoding RNAs; 2.6. Future Directions.

3. Regulation of the Myogenic Program by RNA-Binding Proteins (RBPs)3.1. Cooperation Between MicroRNAs and RBP Regulation of Gene Expression; 4. Satellite Cells Are Regulated by Translational Control Mechanisms Impacting Global Protein Synthesis; 4.1. Regulation of Global Protein Synthesis; 4.2. The Phosphorylation of eIF2α Is a Translational Control Mechanism Responding to Various Cellular Stresses; 4.3. Regulation of Satellite Cells by mTorc1; 5. Concluding Remarks; Acknowledgments; References; Chapter Four: The Composition, Development, and Regeneration of Neuromuscular Junctions.

1. Neuromuscular Junction Composition and Function2. NMJ Development and Maturation; 3. NMJ Regeneration; 4. NMJs and Diseases/Aging; 5. Conclusion and Future Directions; References; Chapter Five: Cellular Biomechanics in Skeletal Muscle Regeneration; 1. Introduction; 2. Matrix Regulation of Skeletal Muscle Regeneration; 2.1. Maintenance of Satellite Cell Quiescence; 2.2. Induction of Satellite Cell Activation; 2.3. Self-Renewal of Muscle Progenitor Cell Reserves; 2.4. Myogenic Commitment and Differentiation; 2.5. Migration of Myogenic Progenitor Cells.