Part-1.Introduction and historical background -- Chapter 1.Overall introduction and rationale, with View from computational biology -- Chapter 2.Integrative/Hybrid Methods Structural Biology: Role of Macromolecular Crystallography -- Chapter 3.View from nuclear magnetic resonance spectroscopy -- Part- 2.New experimental tools enabling hybrid methods -- Chapter 4.Complementary use of electron cryomicroscopy and X-ray crystallography: Structural studies of actin and actomyosin filaments -- Chapter 5.Current solution NMR techniques for structure-function studies of proteins and RNA molecules -- Chapter 6.The PA tag: a versatile peptide tagging system in the era of integrative structural biology -- Chapter 7.Small angle scattering and structural biology: Data quality and model validation -- Chapter 8.Structural investigation of proteins and protein complexes by chemical cross-linking/mass spectrometry -- Chapter 9.Prediction of structures and interactions from genome information -- Chapter 10.A hybrid approach for protein structure determination combining sparse NMR with evolutionary coupling sequence data (EC-NMR) -- Chapter 11.Harnessing the combined power of SAXS and NMR -- Chapter 12.2D Hybrid analysis -- Part-3.New computational tools enabling hybrid methods -- Chapter 13.Hybrid methods for macromolecular modeling by molecular mechanics simulations with experimental data -- Chapter 14.Rigid-body fitting of atomic models on 3D density maps of electron microscopy -- Chapter 15.Hybrid methods for modeling protein structures using molecular dynamics simulations and small-angle X-ray scattering data -- Part-4.Data validation and archives for hybrid methods -- Chapter 16.Archiving pf integrative/hybrid models.