PART 1 Brain Dimorphism -- Dimorphism of human brain: the basis of the gender differences -- PART 2 Disorders of sex Differentiation -- Management of children/adolescents with disorders of sex differentiation (DSD) -- Surgery of feminization in DSD patients -- PART 3 Puberty -- Onset of puberty: genetic, endocrine and environmental factors -- CPP (Central Precocious Puberty): from diagnosis to treatment to get a normal development -- Peripheral precocious puberty: more and more frequent -- Adrenarche and hyper-androgenism -- The hypothalamo-pituitary - ovarian axis during pubertal maturation -- PART 4 Primary and Secondary Amenorrhea -- Primary amenorrhea due to gonadal dysgenesis and primary ovarian failure: diagnosis, management and follow up -- Functional hypothalamic amenorrhea as stress induced defensive system -- Anorexia nervosa in adolescence: psycho-social, clinical and therapeutic aspects -- Long term cardiovascular risks associated with amenorrhea -- PART 5 Growth Disorders -- Female growth disorders: differential diagnosis and management -- Impaired bone development during adolescence: diagnosis, treatment and follow-up -- PART 6 hyperandrogenism -- Management of mild and moderate hyperandrogenism in the adolescent -- PART 7 Pre-menstrual Disorders -- Pre-menstrual disorders and headache in adolescent and young adults -- PART 8 elayed Puberty -- Delayed puberty: impact on fertility -- PART 9 Premature Ovarian Failure -- Premature ovarian failure in adolescence and young adults: From diagnosis to therapy and follow-up for fertility preservation -- PART 10 sexuality, contraception, and pregnancy -- Discovering sexualIty in adolescence -- The choice of the better contraception for the adolescents -- Emergency contraception and abortion -- Pregnancy in adolescents and young adults.