This book constitutes the refereed proceedings of the 10th International Conference on Model and Data Engineering, MEDI 2021, held in Tallinn, Estonia, in June 2021. The 16 full papers and 8 short papers presented in this book were carefully reviewed and selected from 47 submissions. Additionally, the volume includes 3 abstracts of invited talks. The papers cover broad research areas on both theoretical, systems and practical aspects. Some papers include mining complex databases, concurrent systems, machine learning, swarm optimization, query processing, semantic web, graph databases, formal methods, model-driven engineering, blockchain, cyber physical systems, IoT applications, and smart systems. Due to the Corona pandemic the conference was held virtually.