Intro; Title page; Table of Contents; Copyright; Contributors; Preface; Chapter One: Rational Design of Liquid Formulations of Proteins; Abstract; 1 Chemical Instability; 2 Conformational Instability; 3 Colloidal Stability; 4 Interfacial Instability; 5 Conclusions; Chapter Two: Therapeutic Monoclonal Antibodies Delivery for the Glioblastoma Treatment; Abstract; 1 Introduction; 2 Glioblastoma Pathophysiology; 3 Diagnosis of Glioblastoma; 4 Treatment of Glioblastoma; 5 Nanotechnology-Based Drug Delivery Systems Carrying Antibodies to Overcome Current Therapy of Glioblastoma; 6 Conclusion

AcknowledgmentsChapter Three: Dynamical Behavior of Somatostatin-14 and Its Cyclic Analogues as Analyzed in Bulk and on Plasmonic Silver Nanoparticles; Abstract; 1 Introduction; 2 Results and Discussion; 3 Concluding Remarks; 4 Material and Methods; Acknowledgments; Chapter Four: Transglutaminase and Sialyltransferase Enzymatic Approaches for Polymer Conjugation to Proteins; Abstract; 1 Polymer Conjugation to Proteins; 2 Enzymes as Tools for Polymer Conjugation to Proteins; 3 Discussion and Outlook; Acknowledgments

Chapter Five: Chimeric Small Antibody Fragments as Strategy to Deliver Therapeutic PayloadsAbstract; 1 Recombinant Antibodies and Market Size; 2 Structure and Antibody Function; 3 Antibody Fragments and Single-Domain Antibodies; 4 Conjugation Methods for Antibodies; 5 Chemical Modification of Antibody Fragments; 6 Antibody Fragments for Oncology and CNS Applications; 7 Conclusions; Acknowledgments; Chapter Six: Smart Cell-Penetrating Peptide-Based Techniques for Intracellular Delivery of Therapeutic Macromolecules; Abstract; 1 Introduction; 2 An Overview of CPPs

3 Smart CPP-Based, Prodrug Like Techniques4 CPP-Shielding Strategy; 5 CPP-Activating Strategy; 6 Perspective; Acknowledgments; Conflict of Interest; Chapter Seven: In Silico Tools and Databases for Designing Peptide-Based Vaccine and Drugs; Abstract; 1 Introduction; 2 Therapeutic Peptide Repositories; 3 In Silico Tools in Peptide-Based Vaccine Designing; 4 In Silico Tools for Adjuvant Designing; 5 In Silico Tools for Peptide-Based Drug Development; 6 Discussion; 7 Conclusion; Chapter Eight: Protein and Peptides for Elderly Health; Abstract; 1 Introduction

2 Protein Recommendation for Elderly Health3 Protein/Peptide and Elderly Disease; 4 Summary; Chapter Nine: Peptide Derivatives of Erythropoietin in the Treatment of Neuroinflammation and Neurodegeneration; Abstract; 1 Peptide Drugs; 2 Strategies to Improve the Pharmacokinetic Properties of Peptide Drugs; 3 Peptide Drug Discovery; 4 Erythropoietin; 5 Chemically Modified and Nonerythropoietic Erythropoietin Analogs; 6 Growth Factor Mimetic Peptide Drugs; 7 Erythropoietin Mimetic Peptides; 8 Future Perspectives and Conclusion