With two professional assassinations in quick succession, James Bond is quickly elevated to '00' status. Bond's first 007 mission takes him to Uganda where he is to spy on a terrorist, Mollaka. Not everything goes to plan and Bond decides to investigate, independently of MI6, in order to track down the rest of the terrorist cell. Following a lead to the Bahamas, he encounters Dimitrios and his girlfriend, Solange. He learns that Dimitrios is involved with Le Chiffre, banker to the world's terrorist organizations. Intelligence reveals that Le Chiffre is planning to raise money in a high-stakes poker game in Montenegro at Le Casino Royale. MI6 assigns 007 to play against him, knowing that if Le Chiffre loses, it will destroy his organization. 'M' places Bond under the watchful eye of the beguiling Vesper Lynd. At first skeptical of what value Vesper can provide, Bond's interest in her deepens as they brave danger together and even torture at the hands of Le Chiffre. The marathon game proceeds with dirty tricks and violence, raising the stakes beyond blood money and reaching a terrifying climax.

James Bond, 00 olarak ilk misyonuna doğru yola çıkar. Le Chiffre, dünya teröristlerine finans sağlayan adamdır. Montenegro'da bir poker oyununa katılır. Terörist pazarında güvende kalabilmek için parasını geri kazanmak zorundadır. MI6'nın patronu M, Bond'u, Vesper Lynd ile birlikte oyuna göndererek Le Chiffre'nin oyunu kazanmasına engel olmasını ister. Bond, Felix Leiter'den destek alarak ve Vesper'ın da karısı rolünde yanında durmasını sağlayarak kariyerindeki en tehlikeli poker oyununa katılır. Ancak eğer Le Chiffre'e karşı Bond yenilirse, hayatta kalmalarıu mümkün olabilecek midir meçhul.