This study guide is written to support the formal training required to become certified in clinical informatics. The content is structured to define and introduce key concepts with examples drawn from real-world experiences in order to impress upon the reader the core content from the field of clinical informatics. The book is divided into sections that group related chapters based on the major foci of the core content: health care delivery; clinical decision-making; information systems; leadership and managing teams; and professionalism. The chapters do not need to be read or taught in order, although the suggested order is consistent with how the editors have structured their curricula over the years. Clinical Informatics Study Guide: Text and Review serves as a reference for those seeking to independently study for a certifying examination or periodically reference while in practice. It further provides a roadmap for faculty who wish to go deeper in courses designed for physician fellows or graduate students in a variety of clinically oriented informatics disciplines, such as nursing, pharmacy, radiology, and public health.