Evolutionary origins of membrane proteins -- Molecular archeological studies of transmembrane transport systems -- Resource for structure related information on transmembrane proteins -- Topology prediction of membrane proteins: how distantly related homologs come into play -- Transmembrane beta-barrel protein structure prediction -- Multiple alignment of transmembrane protein sequences -- Prediction of re-entrant regions and other structural features beyond traditional topology models -- Dual-topology: one sequence, two topologies -- Predicting the burial/exposure status of transmembrane residues in helical membrane proteins -- Helix-helix interaction patterns in membrane proteins -- Predicting residue and helix contacts in membrane proteins -- Natural constraints, folding, motion, and structural stability in transmembrane helical proteins -- Prediction of three-dimensional transmembrane helical protein structures -- GPCRs: Past, present, and future.