Introduction -- Part I: Foundations - Basic Conceptions in Simulation Model Validation -- What Is Validation of Computer Simulations? -- Simulation Accuracy, Uncertainty, and Predictive Capability -- Verification and Validation Principles from a Systems Perspective -- Errors and Uncertainties -- Part II: Foundations - Validation as a Scientific Method: Philosophical Frameworks for Thinking about Validation -- Invalidation of Models and Fitness-for-purpose -- Simulation Validation from a Bayesian Perspective -- Validation of Computer Simulations from a Kuhnian Perspective -- Understanding Simulation Validation -- Part III: Methodology - Preparatory Steps -- Assessing the Credibility of Conceptual Models -- The Foundations of Verification in Modeling and Simulation -- The Method of Manufactured Solutions for Code Verification -- Validation Metrics: A Case for Pattern-based Methods -- Analyzing Output from Stochastic Computer Simulations -- Part IV: Methodology - Points of Reference and Related Techniques -- The Use of Experimental Data in Simulation Model Validation -- How to Use and Derive Stylized Facts for Validating Simulation Models -- The Users' Judgements -- Validation Benchmarks and Related Metrics -- Part V: Methodology - Mathematical Frameworks and Related Techniques -- Testing Simulation Models Using Frequentist Statistics -- Validation Using Bayesian Methods -- Imprecise Probabilities -- Objective Uncertainty Quantification -- Part VI: Methodology - The Organization and Management of Simulation Validation -- Standards for Evaluation of Atmospheric Models in Environmental Meteorology -- The Management of Simulation Validation -- Valid and Reproducible Simulation Studies -- Part VII: Validation at Work - Best Practice-Examples -- Validation of Particle Physics Simulation -- Validation in Fluid Dynamics and Related Fields -- Astrophysical Validation -- Validation in Weather Forecasting -- Validation of Climate Models: An Essential Practice -- Validation of Agent-based Models in Economics and Finance -- Part VIII: Challenges in Simulation Model Validation -- Validation and Equifinality -- Validation and Overparameterization -- Uncertainty Quantification Using Multiple Models -- Challenges to Simulation Validation in the Social Sciences -- Validation and the Uniqueness of Historical Events -- Part IX: Reflecting on Simulation Validation: Philosophical Perspectives and Discussion Points -- What Is a Computer Simulation and What Does This Mean for Simulation Validation? -- How Do the Validations of Simulations and Experiments Compare? -- How Does Holism Challenge the Validation of Computer Simulation? -- What Types of Values Enter Simulation Validation and What are Their Roles? -- Calibration, Validation, and Confirmation -- Should Validation and Verification Be Separated Strictly? -- The Multi-Dimensional Epistemology of Computer Simulations.