This book constitutes the refereed proceedings of the 12th IAPR-TC-15 International Workshop on Graph-Based Representation in Pattern Recognition, GbRPR 2019, held in Tours, France, in June 2019. The 22 full papers included in this volume together with an invited talk were carefully reviewed and selected from 28 submissions. The papers discuss research results and applications at the intersection of pattern recognition, image analysis, and graph theory. They cover topics such as graph edit distance, graph matching, machine learning for graph problems, network and graph embedding, spectral graph problems, and parallel algorithms for graph problems. .