This book constitutes revised selected papers from the 10th International Workshop on Constructive Side-Channel Analysis and Secure Design, COSADE 2019, held in Darmstadt, Germany, in April 2019. The 14 papers presented together with one keynote and one invited talk in this volume were carefully reviewed and selected from 34 submissions. They were organized in topical sections named: Side-Channel Attacks; Fault-Injection Attacks; White-Box Attacks; Side-Channel Analysis Methodologies; Security Aspects of Post-Quantum Schemes; and Countermeasures Against Implementation Attacks.