Front Cover -- Advances in Carbohydrate Chemistry and Biochemistry -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Hyaluronan and Hyaluronan Fragments -- 1. Introduction -- 2. HA in the Solid State and at Surfaces -- 3. HA in Dilute and in Crowded Solutions -- 4. HA Self-association -- 5. HA Size and Why It Matters -- 5.1. High-Molecular-Mass HA Is the Physiological Protector of Cells -- 5.2. Low-Molecular-Mass HA Stimulates Defensive Cellular Responses -- 5.3. Mechanisms for HA Degradation -- 5.3.1. Hyaluronidases -- 5.3.2. Degradation of HA by ROS/RNS -- 5.3.3. Degradation of HA by Other Chemical and Physical Means -- 6. Experimental Determination of HA Content and Size In Vivo -- 6.1. Isolation Methods -- 6.2. Specific Quantification Methods -- 6.3. Methods for Molecular Mass Analysis -- 6.4. Experimental Findings on HA Content and Size -- 6.4.1. HA in Biological Fluids -- 6.4.2. HA in Tissues -- 7. Diagnostic and Therapeutic Applications -- 7.1. Exogenous HA -- 7.2. HA-Based Medical Diagnostics -- 7.3. Therapeutic Modulation of HA Signaling -- Acknowledgments -- References -- Chapter Two: Application of Porous Materials to Carbohydrate Chemistry and Glycoscience -- 1. Introduction -- 2. Glycoproteins, Glycans, and Glycosylation -- 3. Characteristics of Porous Materials -- 4. Methods for Characterizing Porous Materials -- 5. Glycan and Carbohydrate Enrichment -- 6. Mesoporous Silica and Related Materials -- 6.1. Basic Aspects of Mesoporous Silicas -- 6.2. General Applications of Mesoporous and Porous Silica to Glycans -- 6.3. Mesoporous and Porous Silicas Modified for Boronate Affinity Applications -- 6.4. Carbon-Mesoporous Silica Composites -- 6.5. Lectin-Modified Porous Silica -- 6.6. Controlled Release Applications Involving Mesoporous Silica and Glycans -- 7. Porous Alumina -- 8. Porous Titania -- 9. Mesoporous Carbon.

10. Porous Graphitic Carbon -- 11. Porous Polymers Interacting With or Modified by Carbohydrates -- 11.1. Boronate-Modified Porous Polymers -- 11.2. Hydrophilic Interactions on Porous Polymers -- 11.3. Glycan Release by Enzyme-Modified Porous Polymers -- 11.4. Porous Polymers Modified by or Interacting With Lectins -- 12. Nanoporous Gold -- 13. Future Directions -- Acknowledgments -- References -- Chapter Three: The Synthesis and Biological Characterization of Acetal-Free Mimics of the Tumor-Associated Carbohydrate A ... -- 1. Introduction -- 2. Cancer and Immunotherapy -- 2.1. Overview -- 2.2. TACAs in Cancer -- 3. Synthesis of the Natural TACAs: Historical Overview -- 3.1. Tn Antigen -- 3.2. TF Antigen -- 3.3. sTn Antigen -- 4. Synthetic TACA Antigens as Potential Immunotherapeutics -- 4.1. Overview of Current State of TACA Therapies -- 4.2. Challenges in TACA Vaccine Preparation -- 4.3. Acetal-Free Carbohydrate Antigens -- 5. Synthesis of Carbasugars -- 5.1. Overview -- 5.2. Diels-Alder Approach -- 5.2.1. McCasland Synthesis -- 5.2.2. Ogawa Synthesis -- 5.3. Chemoenzymatic Processes -- 5.4. Ring-Closing Metathesis -- 5.5. Ferrier Type II Rearrangements -- 5.6. Radical Cyclization -- 6. Synthesis of C-Glycosides -- 6.1. Cross-Coupling -- 6.1.1. Heck Reaction -- 6.1.2. Suzuki-Miyaura Coupling -- 6.1.3. Negishi Coupling -- 6.2. Ring-Closing Metathesis -- 6.3. Radical Tethering -- 6.4. Allylation and Related Reactions -- 7. Synthesis of Acetal-Free Tn Antigens -- 8. Synthesis of Acetal-Free TF Antigens -- 9. Synthesis of Acetal-Free sTn Antigens -- 10. Partial Synthesis of Acetal-Free Sialyl Lewis Antigens -- 11. Biological Conjugation and Biological Evaluation of Acetal-Free Mimics -- 11.1. Tn Antigen -- 11.2. TF Antigen -- 11.3. sTn Antigen -- 12. Conclusions and Perspectives -- Acknowledgments -- References -- Author Index -- Subject Index.