Replication -- Chromosomal DNA Replication: On Replicases, Replisomes, and Bidirectional Replication Factories -- Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork -- DNA Polymerases and Diseases -- Replicative Double-Strand Break Repair -- Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing -- Germline Double-Strand Break Repair and Gene Targeting in Drosophila: A Trajectory System throughout Evolution -- Facets of Double-Strand Break Repair -- Structure and Function of Rad50/SMC Protein Complexes in Chromosome Biology -- Mechanisms of Non-Homologous DNA End Joining:Aspects of In Vitro Assays -- Role of p53 in Double-Strand Break Repair -- The Role of Chromatin Structure and Nuclear Architecture in the Cellular Response to DNA Double-Strand Breaks -- DNA Repair and Pleiotropic Interactions -- DNA Base Damage Recognition and Processing -- Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity -- Role of Human Topoisomerase I in DNA Repair and Apoptosis -- Genomic Instability in Fanconi Anaemia and Nijmegen Breakage Syndrome -- Radiation and other Genotoxic Stress -- Induction of DNA Repair Genes in Mammalian Cells in Response to Genotoxic Stress -- Pathways of DNA Double-Strand Break Repair in Mammalian Cells after Ionizing Radiation -- Genomic Instability:Signaling Pathways Orchestrating the Responsesto Ionizing Radiation and Cisplatin -- Ion Irradiation as a Tool to Reveal the Spatiotemporal Dynamics of DNA Damage Response Processes.