Shiga-Toxin Producing Escherichia coli and the Hemolytic Uremic Syndrome: What Have We Learned in the Past 25 Years? -- Global Epidemiology of Pneumococcal Disease-New Prospects for Vaccine Control -- Current Concepts of the Pathogenesis of RSV Bronchiolitis -- How Can We Eradicate Pertussis -- Recognition and Management of Encephalitis in Children -- Microbiology and Management of Pleural Empyema -- Pneumococcal Conjugate Vaccines Probe Studies: The Solution Points to the Problem -- New Findings in Primary Immunodeficiency -- Routine Use of Influenza Vaccine -- Challenges in the Evaluation and Management of Bone and Joint Infections and the Role of New Antibiotics for Gram Positive Infections -- The Significance of Serotype Replacement for Pneumococcal Disease and Antibiotic Resistance -- Childhood Intra-thoracic Tuberculosis -- The Antibiotic Pipeline in Pediatrics -- Paediatric Drug Development and Clinical Trials -- Influenza in Pregnancy: The Case for Prevention -- Febrile Neutropenia in Children with Cancer -- The PANDAS Syndrome -- Fever in the Returned Paediatric Traveller -- Molecular Diagnostics of Primary Immunodeficiencies: Benefits and Future Challenges -- Human Genetic Resistance to Malaria.