Preface, Christoph Wittmann, Sang Yup Lee -- 1. Genome-scale network modeling, Sang Yup Lee et al -- 2. Kinetic modeling of metabolic networks, Daniel C. Zielinski and Bernhard O. Palsson -- 3. Design of superior cell factories based on systems wide omics analysis, Hiroshi Shimizu et al -- 4. Technologies for bio-systems engineering, Sven Panke et al -- 5. Systems metabolic engineering of Escherichia coli for chemicals, materials, biofuels, and pharmaceuticals, Sang Yup Lee et al -- 6. Systems metabolic engineering of Corynebacterium glutamicum for biobased production of chemicals, materials and fuels, Judith Becker, Stefanie Kind, Christoph Wittmann -- 7. Towards a synthetic biology of the stress-response and the tolerance phenotype: systems understanding and engineering of the Clostridium acetobutylicum stress-response and tolerance to toxic metabolites, Eleftherios T. Papoutsakis, Keith V. Alsaker -- 8. Model-based design of superior cell factory: an illustrative example of Penicillium chrysogenum, I. Emrah Nikerel -- 9. Bridging Omics Technologies with Synthetic Biology in Yeast Industrial Biotechnology, António Roldão, Il-Kwon Kim, Jens Nielsen -- 10. Design of superior cell factories for a sustainable biorefinery by synthetic bioengineering, Tomohisa Hasunuma, Fumio Matsuda, Akihiko Kondo -- 11. Systems-level analysis of cancer metabolism, Paulo A. Gameiro, Christian M. Metallo, Gregory Stephanopoulos -- Index.