Part 1. SOCE - Fundamental Mechanistic Concepts -- 1. Introduction -- 2. STIM/Orai Structures: Isolated and in Complex -- 3. Orai, the Pore-Forming Subunit of the CRAC Channel -- 4. The Interactions between STIM and Orai -- 5. Conformational Coupling between STIM and Orai in the Activation of Store-operated Ca2+ Entry -- 6. Regulation of STIM and Orai by Thiol Modifications -- 7. Light-operated Ca2+ entry Through Engineered CRAC Channels -- 8. Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes -- 9. Contribution of TRPC1 in Store-operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function -- 10. Auxiliary Proteins of the STIM/Orai Complex -- Part 2.SOCE - Crosstalk between Organelle and Cellular Compartments -- 11. Introduction -- 12. The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE -- 13.TRPC Proteins as a Link between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores -- 14. The Role of Mitochondria in the Activation/Maintenance of SOCE Store-operated Ca2+ Entry and Mitochondria -- 15. The Role of Mitochondria in the Activation/Maintenance of SOCE Membrane Contact Sites as Signaling Hubs Sustaining Store-operated Ca2+ Entry --  16.The Role of Mitochondria in the Activation/Maintenance of SOCE - The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility and Location to Store-operated Ca2+ Entry -- 17.Tissue specificity - The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling -- 18. Tissue specificity SOCE - Implications for Ca2+ Handling in Endothelial Cells -- 19. Tissue specificity - Store-operated Ca2+ Entry in Cardiac Myocytes -- Part  3. SOCE - Molecular and Cellular (Patho) Physiology -- 20. Introduction -- 21. Immunological Disorders - Regulation of Ca2+ Signaling in T Lymphocytes -- 22. Cardiovascular and Hemostatic Discorders Role of STIM and Orai Proteins in Vascular Disorders -- 23. Cardiovascular and Hemostatic Discorders SOCE and Ca2+ Handling in Platelet Dysfunction -- 24. Cardiovascular and Hemostatic Discorders - SOCE in Cardiovascular Cells - Emerging Targets for Therapeutic Intervention -- 25. Cardiac Remodelling and Disease - SOCE and TRPC Signaling in Cardiac Pathology -- 26. Cardiac Remodelling and Disease - Current Understanding of STIM1/Orai1-mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology -- 27. Neurological and Motor Disorders - Neuronal Store-operated Ca2+ Signaling: An Overview and its Function -- 28. Neurological and Motor Disorders - TRPC in Skeletal Muscle -- 29. Fertility - Store-operated Ca2+ Entry in Germ Cells: Role in Egg Activation -- 30. Metabolic Disorders and Cancer - Hepatocyte Store-operated Ca2+ Channels in Non-alcoholic Fatty Liver Disease -- 31. Metabolic Disorders and Cancer - Store-operated Ca2+ Entry in Cancer: Focus on IP3R-mediated Ca2+ Release from Intracellular Stores and its Role in Migration and Invasion.