Target Mitochondria -- SECTION I-Mitochondrial Biology -- Introduction: Mitochondria: the cell furnace -- MItochondria: Where are They Coming From? -- Mitochondrial Dynamics: A journey from Mitochondrial Morphology to MItochondrial Function and Quality -- Mitochondrial ROS, Oxidative Stress.and Aging- The Mitochondrial Permeability Transition Pore -- Mitochondrial Regulation of Cell Death -- MItochondria in Liver Diseases -- Mitochondria in Liver Regeneration,Energy Metabolism, and Posthepatectomy Liver Dysfunction -- MItochondrial Remodeling in Cancer -- Mitochondria in Kidney Disease -- CNS diseases and disruption of Mitochondria -- Mitochondrial disruption in cardiovascular diseases -- .Drug-inducing Mitochondrial Toxicity -- MItochondrial DNA: Functions and Role in Acquired Diseases -- SECTION II-MItochondrial Therapeutics: From the Bench to Industry and Patient -- The Evolution of Mitochondrial Toxicity Assessment in Industry -- Designing Mitochondrial-Active Molecules: The Road to MitoQ and Beyond -- Recovering Mitochondrial Function in Patients' Fibroblasts -- Targeting Mitochondria with Sweat: Improving Mitochondrial Function with Physical Activity -- Modulation of Cell Fate by Tauroursodexycholic Acid: All Paths Lead to Mitochondria -- Pharmacological Targeting of the Mitchondrial Permeability Transition Pore -- Strategies to Preserve/Improve Mitochondrial Function in Organ Preservation Solutions -- MItochondrial Targeted Redox Active Compounds and the Astrocytemotoneuron Axis: relevance for the Treatment of Amyotrophic Lateral Sclerosis -- Targeting the Mitochondrial Genome Through a Nanocarrier and the Regulation of the Mitochondrial Gene Experssion -- Mitochoncrial Dysfunction and Chronic Disease: Treatment with Membrane Lipid Replacement and other Natural Supplements -- Development of Mitochondrial-Directed Plastoquinones -- Targeted Mitochondrial Genome Editing -- Targeting Therpeutic Nucleic Acids into Mitochondria: A Long Challenge -- Cell Permeable Peptides Targeting Mitochondria -- MItochondrial -Directed Cancer Therapy -- SkQ1: The Road from the Bench to the Market -- MItochondrial Follies: Comic.