The International Symposium on Distributed Computing and Artificial Intelli-gence (DCAI´10) is an annual forum that brings together past experience, current work and promising future trends associated with distributed computing, artificial intelligence and their application to provide efficient solutions to real problems. The present edition has been held at the Polytechnic University of Valencia, from 7 to 10 September 2010, within the Congreso Español de Informática (CEDI 2010). Technology transfer in this field is still a challenge, with a large gap between academic research and industrial products. This edition of DCAI aims at contributing to reduce this gap, with a stimulating and productive forum where these communities can work towards future cooperation with social and economi-cal benefits.