This book - in conjunction with the two volumes CCIS 0015 and LNAI 5226 - constitutes the refereed proceedings of the 4th International Conference on Intelligent Computing, ICIC 2008, held in Shanghai, China, in September 2008. The 152 revised full papers of this volume were carefully reviewed and selected from a total of 2336 submissions. The papers are organized in topical sections on biological and quantum computing, intelligent computing in bioinformatics, computational genomics and proteomics, intelligent computing in signal processing, intelligent computing in pattern recognition, intelligent computing in communication, intelligent agent and web applications, intelligent fault diagnosis, intelligent control and automation, intelligent data fusion and security, intelligent prediction and time series analysis, natural language processing and expert systems, intelligent image/document retrievals, network-based intelligence and automation, intelligent robot systems based on vision technology, and computational intelligence for image analysis.