This book is composed by the papers written in English and accepted for presentation and discussion at The 2021 International Conference on Information Technology & Systems (ICITS 21), held at the Universidad Estatal Península de Santa Elena, in Libertad, Ecuador, between the 10th and the 12th of February 2021. ICITS is a global forum for researchers and practitioners to present and discuss recent findings and innovations, current trends, professional experiences and challenges of modern information technology and systems research, together with their technological development and applications. The main topics covered are information and knowledge management; organizational models and information systems; software and systems modelling; software systems, architectures, applications and tools; multimedia systems and applications; computer networks, mobility and pervasive systems; intelligent and decision support systems; big data analytics and applications; human-computer interaction; ethics, computers & security; health informatics; and information technologies in education.