Recurrent Themes in Biomedical Informatics -- The Computer Meets Medicine and Biology: Emergence of a Discipline -- Biomedical Data: Their Acquisition, Storage, and Use -- Biomedical Decision Making: Probabilistic Clinical Reasoning -- Cognitive Science and Biomedical Informatics -- Essential Concepts for Biomedical Computing -- System Design and Engineering in Health Care -- Standards in Biomedical Informatics -- Natural Language and Text Processing in Biomedicine -- Imaging and Structural Informatics -- Ethics and Health Informatics: Users, Standards, and Outcomes -- Evaluation and Technology Assessment -- Biomedical Informatics Applications -- Electronic Health Record Systems -- Management of Information in Healthcare Organizations -- Consumer Health Informatics and Telehealth -- Public Health Informatics and the Health Information Infrastructure -- Patient-Care Systems -- Patient-Monitoring Systems -- Imaging Systems in Radiology -- Information Retrieval and Digital Libraries -- Clinical Decision-Support Systems -- Computers in Medical Education -- Bioinformatics -- Biomedical Informatics in the Years Ahead -- Health Care Financing and Information Technology: A Historical Perspective -- The Future of Computer Applications in Biomedicine.