Bone and Cartilage Engineering presents the theory and practice of cell-based regeneration of skeletal defects. Much of the focus is on the importance of the cell biological and biomaterial aspects for engineering a clinically relevant device. The basic key techniques for optimal engineering outcomes including cell and organ culture, biomaterial development, and bioreactor use are described in detail and highlighted by multiple figures. Cell-matrix and cell-biomaterial interactions are discussed for evaluating different tissue engineering strategies. Focusing also on preclinical models, clinical applications, ethical, and regulatory issues, this book provides state-of-the art information on cell-based skeletal tissue engineering.