Historical Perspective on the Classification and Nomenclature of Pulmonary Hypertension -- The Defining Characteristics of Pulmonary Arterial Hypertension -- Pulmonary Hypertension in Patients Without Pulmonary Arterial Hypertension -- Epidemiology of Pulmonary Hypertension: From Quaternary Referral Centre to the Community -- The Effects of Chronic Hypoxia on Inflammation and Pulmonary Vascular Function -- Genetics of Pulmonary Vascular Disease -- Novel Mechanisms of Disease: Network Biology and MicroRNA Signaling in Pulmonary Hypertension -- Pulmonary Hypertension as a Metabolic Disease -- Renin-Angiotensin-Aldosterone and other Neurohumoral Factors in the Pathogenesis of Pulmonary Hypertension -- Animal Models of Pulmonary Hypertension -- The Cardiopulmonary Hemodynamic Evaluation of Pulmonary Hypertension -- Advanced Imaging in Pulmonary Hypertension -- Assessing Disease State in the Pulmonary Vasculature in Clinical Practice and Research -- Biomarkers and other Methods for Assessing Patient Progress -- Pulmonary Circulatory - Right Ventricular Uncoupling: New Insights into Pulmonary Hypertension Pathophysiology -- Contemporary Pharmacotherapies Involving Nitric Oxide, Prostacyclin, and Endothelin Receptor Signaling Pathways -- Determining the Optimal Approach to Initiating Oral, Inhaled, and Intravenous Therapies in Clinical Practice: Sequential Goal-Directed Therapy is Best -- Counterpoint: Determining the optimal approach to initiating oral, inhaled, and intravenous therapies in clinical practice: Maximal upfront therapy is best -- Surgery, Devices, Transplantation and Other Interventional Options for the Treatment of Advanced Pulmonary Hypertension -- Patient Registries in Pulmonary Arterial Hypertension:  the Role of Survival Equations and Risk Calculators -- Support Care for the Pulmonary Hypertension Patient -- Special Considerations for the Pulmonary Hypertension Patient -- The Future of Pulmonary Hypertension.