Part 1. Hypothalamic-pituitary-adrenal axis regulation of the body, brain, and inflammation -- 1. Glucocorticoid regulation of body composition and metabolism -- 2. Glucocorticoid regulation of neurocognitive and neuropsychiatric function -- 3. Glucocorticoids: Inflammation and Immunity -- Part 2. Cushing's Syndrome -- 4. Pathogenesis, diagnosis and localization of Cushing's: Molecular pathogenesis of primary adrenal Cushing's syndrome -- . 5. Pathogenesis, diagnosis and localization of Cushing's -- 5. Pathogenesis, diagnosis and localization of Cushing's: Pathogenesis and treatment of aggressive corticotroph pituitary tumors - Yang Shen and Anthony P Heaney -- 6. Pathogenesis, diagnosis and localization of Cushing's: Neoplastic/Pathologic and Non-neoplastic/Physiologic Hypercortisolism: Cushing verses Pseudo-Cushing Syndromes -- 7. Pathogenesis, diagnosis and localization of Cushing's: Imaging strategies for localization of ACTH - secreting tumors -- 8. Recent Advances in the medical and surgical treatment of Cushing's: Surgical Treatment of Cushing's disease -- 9. Recent Advances in the medical and surgical treatment of Cushing's: Medical therapies in Cushing's syndrome -- 10. New themes in Cushing's definitions and outcomes: Mild adrenal cortisol excess - 11. New themes in Cushing's definitions and outcomes: Long term effects of prior Cushing's syndrome -- 12. New themes in Cushing's definitions and outcomes: Cushing's disease: refining the definition of remission and recurrence -- Part 3. Beyond Cushing's: Glucocorticoid sensitivity, regulation and the metabolic syndrome -- 13. Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis through a Mutated Glucocorticoid Receptor -- 14. Cortisol metabolism as a regulator of the tissue-specific glucocorticoid action -- 15. Obesity and metabolic syndrome: a phenotype of mild long-term hypercortisolism.