1.Diagnostic issues of depression -- 1-1.Major depression and bipolar depression: similarity, difference and contemporary treatment approach -- 1-2.Biomarkers of depression-potential diagnostic tools -- 1-3.Diagnosis of depression: from clinical classification to biological classification -- 1-4.Application of neuroimaging in the diagnosis and treatment in depression -- 2.Clinical manifestations of depression -- 2-1.Anhedonia as a crucial factor of depression; assessment, neurobiological underpinning and treatment -- 2-2.Sleep and sleep disorders in depression -- 2-3.Chronobiology and treatment in depression -- 2-4.Suicide in depression: risk factors, neurobiology and treatment -- 2-5.Cognitive dimension of depression; assessment, neurobiology and treatment -- 2-6.Risk factors and prevention strategy of depression in childhood and adolescence -- 2-7.Neurobiology and risk factors in late life depression -- 3.Complicated clinical manifestations of depression -- 3-1.Overlapping chronic pain and depression: pathophysiology and management -- 3-2.Clinical, biological and therapeutic characteristics between depression with and without medical illness -- 3-3.Biological mechanism underlying the link Depression and cardiovascular disease -- 3-4.Bunout syndrome and depression -- 3-5.The link between obesity and depression: exploring shared mechanisms -- 3-6.Biomarkers, detection and therapeutic approaches for antenatal and postnatal depression -- 4.Therapeutic issues of depression -- 4-1.Ketamine: a promising rapid-acting antidepressant in depression -- 4-2.Antidepressant therapy for depression: An update -- 4-3.The use of atypical antipsychotics in treatment of depression: efficacy and safety -- 4-4.Neurobiology and therapeutic approach in treatment-resistant depression (TRD) -- 4-5.Clinical application of neurostimulation in depression -- 4-6.Combination therapy of pharmacotherapy and psychotherapy in depression: Is it really superior to either treatment alone? -- 4-7.Mindfulness-based cognitive therapy for depression: preference to internet-based mental health and psychotherapy approaches in mood disorders -- 4-8.Current research on complementary and alternative medicine (CAM) in the treatments of depression: evidence based review.