Part 1. Basic science -- Platelets: at the interface between inflammation and repair process -- Characterization of plasma rich in growth factor: content and formulation -- Effects of PRGF on cells and tissues of musculoskeletal system: from muscle to articular cartilage -- Regeneration: connecting the dots among hemostasis and clotting, immune system, and fibrogenesis -- PRGF molecular intervention to enhance muscle perfusion and tissue remodeling -- Part 2. Oral and Maxillofacial surgery -- The use of plasma rich in growth factor in the treatment of post-extraction defects -- Efficacy and safety of PRGF versus platelet rich fibrin in post-extraction defects -- An autologous treatment to a challenging pathology medication-related osteonecrosis of the jaw. Part 3. Orthopaedics & Sports Medicine -- A biological approach to apply plasma rich in growth factors on joint tissues -- Scientific evidence of the effects of PRGF on musculoskeletal tissues in animal model -- A new approach to treat joint and cartilage injuries: intraosseous infiltrations of PRGF -- Knee Osteoarthritis: one versus two cycles of PRGF infiltrations treatment -- Application of PRGF on Sports-related injuries -- Why to use Plasma rich in growth factors on the repair of damaged tendons -- Infiltrations of PRGF to treat ligament injuries -- Treatment of injured peripheral nerves with PRGF: from bench to patient -- Treatment of tendinopathies with Plasma rich in growth factors -- Intradiscal and intra-articular facet infiltrations with plasma rich in growth factors to treat chronic low back pain.