Part I Menopause: symptoms and neuroendocrine impact Intracrinology made menopause possible -- From menopause to aging: endocrine and neuroendocrine biological changes -- Brain impact of sex steroids withdrawall of the menopause -- Climacteric symptoms: importance and management -- Part II Fertility 2016 IMS Recommendations on women's midlife health, "POI" and menopause hormone therapy (MHT) -- Female infertility and autoimmunity -- Is IVF/ICSI/ET reasonable beyond the female age of 40 years? -- IVF: new developments in patient tailored ovarian stimulation -- Oocyte donation in peri-menopausal and menopausal women -- Part III Thyroid disorders, polycystic ovary and metabolic syndrome Thyroid disorders in climacteric women -- Thyroid function and pregnancy outcome after ART: what is the evidence? -- PCOS: implications of cardio-metabolic dysfunction -- Why Metformin is so important for prevention and treatment in climacteric women? -- Metabolic changes during menopausal trans ition -- Weight and body composition management after menopause -- Part IV Bone and cardiovascular impact Healthy bones after menopause - what has to be done? -- The effect of menopause and HRT on coronary heart disease -- How to prevent cardiovascular disorders: influence of gonadal steroids on the heart -- Part V Benign breast diseases, BRCA mutation and breast cancer Risk reducing surgery and treatment of menopausal symptoms in BRCA mutation carriers (and other high risk women) -- Benign breast disease during women's life -- Treatment of menopausal symptoms in breast cancer survivors -- Myo-inositol and Inositol Hexaphosphate (IP6) in the treatment of breast cancer -- Part VI Menopause symptoms: the therapies The true risks of hormone replacement therapy -- Menopausal hormone therapy customization -- Vulvovaginal atrophy (VVA) and Genitourinary Syndrome of Menopause (GSM): Advances in management -- Menopause symptoms: new treatment options -- Intravaginal DHEA for the treatment of vaginal atrophy closest to physiology -- Part VII Surgical challenges after menopause: problems and solutions Bladder dysfunction and urinary incontinence after the menopause: hormones, drugs or surgery? -- When is ovarectomy and when tubectomy indicated at necessary hysterectomies beyond the reproductive age? -- Pelvic floor reconstructive surgery in ageing women: tailoring the treatment to each woman's needs.