PART 1: INTRODUCTION.-The Disease-Based Treatment of Pain -- Algorithms of Pain Treatment .-The Opioid Epidemic and the Need for a Pain Strategy.-PART 2: ANATOMY AND PHYSIOLOGY OF PAIN.-Nerve Function and Neurons.-Peripheral Nerve Anatomy.-Spinal Cord Anatomy.-Anatomy of the Brain and Brainstem.-Mediators of Pain and Pain Processing.-Taxonomy of Pain.-Pain Relieving Mechanisms in Neuromodulation.-PART 3: PSYCHOLOGY OF PAIN.-The Normal Response to Pain.-Pain and Suffering.-Social Impact of Pain Response.-Role of Religion and Spirituality in the Patient Pain Experience -- Anxiety and Depression in Patients with Chronic Pain.-Psychological Treatments to Improve Outcomes.-Psychological Evaluation for Those Receiving Devices for the Treatment Of Pain.-PART 4: PHARMACOLOGICAL TREATMENT OF PAIN.-Acetaminophen and Nonsteroidal Anti-inflammatory Drugs.-Anticonvulsants in the Treatment of Pain.-Botulinum Toxin.-Sodium Channel Antagonists.-Anti-Spasmodics and Muscle Relaxants.-Antidepressants in Pain Management.-Ketamine and NMDA-Receptor Antagonists.-Novel Analgesics.-Injectable Corticosteroids.-Topical Therapies -- Opioids for Chronic Non-Cancer Pain.-Opioids for Cancer Pain and Hospice Care.-Pharmacogenetics and Pharmacogenomics of Pain Treatment .-PART 5: INTERVENTIONAL TREATMENT OF PAIN.-Radiation Safety.-Radiofrequency Ablation.-Basic Science of Radiofrequency.-Cryotherapy.-Chemodenervation: Neurolytic Blockade and Potent Neurotoxins for the Treatment of Cancer Pain -- Blockade of the Nerves of the Head and Face.-Ganglion Blocks of Head and Face.-Destructive procedures of the Head and Face .-39. Interlaminar Approach for Cervical Epidural Steroid Injection.-Cervical Transforaminal Epidural Injections.-Diagnostic Cervical Nerve Root Blocks.-Cervical Facet Joint Injection and Medial Branch Blocks .-Cervical Facet Radiofrequency Neurotomy.-Intercostal Nerve Block.-Intercostal Nerve Block.-Thoracic Interlaminar Epidural Steroid Injection.-Thoracic Facet and Medial Branch Blocks.-Radiofrequency Ablation in the Thoracic Spine.-Lumbar Interlaminar Epidural Injection.-Lumbar Transforaminal Epidural Corticosteroid Injections.-Lumbar Facet and Medial Branch Block.-Sacroiliac Joint Injection .-Sacroiliac Joint Radiofrequency.-Sacroiliac Joint Fusion.-Caudal Epidural Injection.-Stellate Ganglion Block.-Lumbar Sympathetic Block.-Celiac Plexus Block and Superior Hypogastric Plexus Block.-Ganglion Impar Block.-Large Joint Injections.-PART 6: NEUROMODULATION -- Deep Brain Stimulation.-Motor Cortex Stimulation.-Occipital Nerve Stimulation.-Sphenopalatine Ganglion Block.-Percutaneous Cervical Spinal Cord Stimulation.-Surgical Leads for the Cervical Spine.-Dorsal Root Ganglion Stimulation-Cervical Spine.-Percutaneous Thoracic Neurostimulation for Chronic Pain.-Surgical Lead for the Thoracic Spine.-Percutaneous Lumbar Stimulation.-Thoracic and Lumbar Dorsal Root Ganglion Spinal Stimulation.-Percutaneous Sacral Nerve Stimulation.-Sacral Dorsal Root Ganglion Spinal Stimulation.-Peripheral Nerve Stimulation.-Stimulation Methods and Device Choices: Dorsal Root Ganglion Stimulation, Spinal Cord Stimulation, and Peripheral Nerve Stimulation.-Patient Selection.-Wound Closure and Surgical Healing.-Complications of Neuromodulation -- PART 7: NEUROAXIAL THERAPIES.-Intrathecal Pharmacology.-Patient Selection -- Intrathecal Device Considerations.-Intrathecal Agents and Algorithms: Review of PACC 2012 and 2017 Guidelines and Beyond.-Implantable Drug Delivery Systems for Cancer Pain and End Of Life Care.-Intrathecal Drug Delivery Systems for Chronic Non-Cancer Pain.-IDDS For Movement Disorders.-Ziconitide for Intrathecal Use.-PART 8: REGENERATIVE THERAPIES FOR CHRONIC PAIN.-Scientific Bases of PRP Therapy.-Scientific Basis for Stem Cell Therapy.-Stem Cells.-Regenerative Therapies for Chronic Intradiscal Pain.-PRP Therapies (Tendons, Joints, Spine) .-PART 9: INTRADISCAL AND MINIMALLY INVASIVE STRUCTURAL SURGERIES.-Discography.-Endoscopic Discectomy.-Vertebral Augmentation for Painful Vertebral Compression Fractures.-Vertebroplasty and other methods of vertebral augmentation.-Minimally Invasive Lumbar Decompression.-Interspinous Process Spacers for Indirect Lumbar Decompression.-PART 10. REHABILITATION AND ADJUVANT THERAPIES FOR PAIN.-Physical Therapy.-Acupuncture.-PART 11. ADMINISTRATIVE CONSIDERATIONS.-Cybersecurity of Medical Devices: Past, Present, and Future -- Coding and Billing.-Medicare Payment Quality Measures -- .