Part I: Achieving Stereotactic Precision -- Traditional and Mini-Frames -- Stereotactic Robots -- Intraoperative Magnetic Resonance Imaging and Computed Tomoraphy -- Frameless Image Guidance in Stereotactic Radiosurgery -- Part II: Defining Trajectories and Targets -- Principles of Safe Sterotactic Trajectories -- Structural Imaging and Target Visualization -- Network-Based Imaging and Connections -- Microelectrode Recording in Neurosurgical Patients -- Local Field Potentials and ECoG -- Awake Testing to Confirm Target Engagement -- Cloud-Based Stereotactic and Functional Neurosurgery and Registries -- Part III: The Biophysics of Stereotactic Therapy -- Responsive Neurostimulation -- Spinal Stimulation -- Peripheral Nerve Stimulation -- Non-Invasive Central Neuromodulation with Transcranial Magnetic Stimulation -- Ablation: Radiofrequency, Laser, and HIFU -- Radiosurgery -- Part IV: Diseases and Targets -- Parkinson's Disease: Deep Brain Stimulation -- Parkinson's Disease: Lesions -- Deep Brain Stimulation and Essential Tremor -- Essential Tremor: Lesions -- Dystonia -- Invasive Monitoring in Epilepsy Surgery -- Epilepsy: Mesial Temporal -- Neocortical Epilespy -- Stereotactic Neurosurgery for the Management and Treatment of Pediatric Epilepsy -- Epilepsy: Neuromodulation -- Deep Brain Stimulation for Treatment-Resistant Depression -- Deep Brain Stimulation for Obsessive Compulsive Disorder -- Stereotactic Lesion Procedures for Obsessive-Compulsive Disorder -- Deep Brain Stimulation for Gilles de la Tourette Syndrome -- Neuromodulation for Chronic Pain -- Chronic Pain: Lesion -- Deep Brain Stimulation for Cluster Headache -- Part V: The Future of Functional Neurosurgery -- Developing New Indications: Strategies and Hurdles to Discovery -- Imaging: Patient Selection, Targeting, and Outcome Biomarkers -- The Design of Clinical Studies for Neuromodulation -- Registries and Big Data.