This book provides state-of-the-art and up-to-date discussions on the pathology-related considerations and implications in the field of orthopaedic biomechanics. It presents fundamental engineering and mechanical theories concerning the biomechanics of orthopaedic and anatomical structures, and explores the biological and mechanical features that influence or modify the biomechanics of these structures. It also addresses clinically relevant biomechanical issues with a focus on diagnosis, injury, prevention and treatment. The first 12 chapters of the book provide a detailed review of the principles of orthopaedic biomechanics in the musculoskeletal system, including cartilage, bone, muscles and tendon, ligament, and multiple joints. Each chapter also covers important biomechanical concepts relevant to surgical and clinical practice. The remaining chapters examines clinically relevant trauma and injury challenges in the field, including diagnostic techniques such as movement analysis and rehabilitation intervention. Lastly it describes advanced considerations and approaches for fracture fixation, implant design, and biomaterials.