PREFACE -- I Epidemiology -- II Pathology and Biology -- 1 Pathology of brain metastases -- 2 Translationnal approaches -- 3 Molecular mechanisms driving brain metastases development -- 4 Genomics characterization of BM -- 5 BM cell partners and tumor microenvironment -- 6 Experimental models of Brain Metastases -- III Clinical presentation and symptom management -- 7 Clinical presentation -- 8 Epilepsy in CNS metastases -- 9 Safety, tolerability and use of steroids in CNS metastasis patients -- 10 Thrombo-embolic complications in BM patients -- IV Imaging -- 11 BM diagnosis and monitoring -- 12 Metabolic imaging of BM -- 13 Radiation necrosis and progression assessment and definition -- V Surgery -- 14 Modern surgical techniques -- 15 Quality of surgical resection assessment -- 16 Indications and emerging concepts in the era molecular biology -- VI Radiation Therapy -- 17 Stereotatic radiosurgery -- 18 WBRT -- 19 Combined radiation therapy and systemic treatment -- VII Systemic treatment -- 20 Lung -- 21 Breast.-. 22 Melanoma -- 23 Miscellaneous -- VIII Neurocognition and QoL -- IV Leptomeningeal disease -- X Prevention/Prohylaxis strategies -- XI Prognosis and prognostic models -- XII Clinical trials / Endpoints and outcome assessment. .