The Coagulative cascade -- Clinical Indications for Direct Acting Oral Anticoagulants -- Pharmacokinetic and pharmaco-dynamic of DOACDrug-drug interaction with DO-ACsDirect Oral Anticoagulant Reversal for Management of Bleeding and Emergent Surgery -- Risk stratification for and use of DOAC therapies for stroke prevention in patient with atrial fibrillationUse of DOAC in patients with kidney disease -- Anticoagulation In Elderly Patients With Atrial FibrallationThe "Obesity Paradox" And The Use Of NOAC -- Direct Oral Anticoagulation In Cancer Patients -- DOACs and Dementia in Patients with Atrial Fibrillation -- Non-Vitamin K Antagonists and Cardiac Implantable Electronic Devices -- Direct Oral Anticoagulants and Atrial Fibrillation Ablation -- DOAC therapy in patients post left atrial appendage occlusion or isolation -- Use of Direct Oral Anticoagulants after Transcatheter Aortic Valve Replacement -- Use of Direct Oral Anticoagulants after Percutaneous Coronary Intervention -- Direct oral anticoagulants and Left Ventricular Thrombosis: the evidence for a good therapeutic approach.