General Outlook and Possibilities -- Literature-Based Discovery? The Very Idea -- The Place of Literature-Based Discovery in Contemporary Scientific Practice -- The Tip of the Iceberg: The Quest for Innovation at the Base of the Pyramid -- The 'Open Discovery' Challenge -- Where is the Discovery in Literature-Based Discovery? -- Methodology and Applications -- Analyzing LBD Methods using a General Framework -- Evaluation of Literature-Based Discovery Systems -- Factor Analytic Approach to Transitive Text Mining using Medline Descriptors -- Literature-Based Knowledge Discovery using Natural Language Processing -- Information Retrieval in Literature-Based Discovery -- Biomedical Application of Knowledge Discovery.