An Improved BigDAWG Architecture -- Multi-Model Database Management Systems - a Look Forward -- Progressive Interactions Between Data Sources -- TDM: A Tensor Data Model for Logical Data Independence in Polystore Systems -- Sketching data structures for massive graph problems -- Managing Structurally Heterogeneous Databases in Software Product Lines -- PDSPTF: Polystore Database System for Scalability and Access to PTF Time-domain Astronomy Data Archives -- API Federation in the BigDAWG Polystore -- Augmented Therapy with Online Support Groups -- RHCS - A Clinical Recommendation System for Geriatric Patients -- Implementation of a Medical Coding Support System by Combining Approaches: NLP and Machine Learning -- Building a Research-Quality Copy Number Variation Data Repository for Translational Research -- Data-Driven Genomic Computing: Making Sense of the Signals from the Genome -- DEAME - Differential Expression Analysis Made Easy.