This book constitutes the thoroughly refereed papers of the workshops held at the 10th International Conference on New Trends in Model and Data Engineering, MEDI 2021, held in Tallinn, Estonia, in June 2021: Workshop on moDeling, vErification and Testing of dEpendable CriTical systems, DETECT 2021; Symposium on Intelligent and Autonomous Systems, SIAS 2021; Worjshop on Control Software: Methods, Models, and Languages, CSMML 2021; Blockchain for Inter-Organizational Collaboration, BIOC 2021; The International Health Data Workshop, HEDA 2021. The 20 full and the 4 short workshop papers presented were carefully reviewed and selected from 61 submissions. The papers are organized according to the workshops: Workshop on moDeling, vErification and Testing of dEpendable CriTical systems, DETECT 2021; Symposium on Intelligent and Autonomous Systems, SIAS 2021; Worjshop on Control Software: Methods, Models, and Languages, CSMML 2021; Blockchain for Inter-Organizational Collaboration, BIOC 2021; The International Health Data Workshop, HEDA 2021.