This book constitutes selected and revised papers from the 20th International Conference on Mathematical Modeling and Supercomputer Technologies, MMST 2020, held in Nizhny Novgorod, Russia, in November 2020. Due to the COVID-19 pandemic the conference was held online. The 25 full papers and 8 short papers presented in the volume were thoroughly reviewed and selected from the 106 submissions. They are organized in topical secions on computational methods for mathematical models analysis; computation in optimization and optimal control; supercomputer simulation. .