These proceedings present the latest information on software reliability, industrial safety, cyber security, physical protection, testing and verification for nuclear power plants. The papers were selected from more than 80 submissions and presented at the First International Symposium on Software Reliability, Industrial Safety, Cyber Security and Physical Protection for Nuclear Power Plants, held in Shanghai, China on December 10-14, 2015. The primary aim of this symposium was to provide a platform to facilitate the discussion for comprehension, application and management of digital instrumentation, control systems and technologies in nuclear power plants. The book reflects not only the state of the art and latest trends in nuclear instrumentation and control system technologies, but also China's increasing influence in this area. It is a valuable resource for both practitioners and academics working in the field of nuclear instrumentation, control systems and other safety-critical systems, as well as nuclear power plant managers, public officials and regulatory authorities.