Introduction -- A Tale of Two Animats: What does it take to have goals? (Larissa Albantakis).- Meaning and Intentionality = Information + Evolution (Carlo Rovelli).- Von Neumann Minds: A Toy Model of Meaning in a Natural World (Jochen Szangolies).- Origin Gaps and the Eternal Sunshine of the Second-Order Pendulum (Simon DeDeo).- Agent Above, Atom Below: How agents causally emerge from their underlying microphysics  (Erik P Hoel) -- Bio from Bit  (Sara Imari Walker) -- I Think, Therefore I Think You Think I Am (Sophia Magnusdottir) -- World without World: Observer-Dependent Physics  (Dean Rickles).- The role of the observer in goal-directed behavior (Ines Samengo) -- Wandering Towards Physics: Participatory Realism and the Co-Emergence of Lawfulness  (Marc Séguin) -- God's Dice and Einstein's Solids (Ian Durham).-  Finding Structure in Science and Mathematics (Noson S. Yanofsky) -- From Athena to AI: the past and future of intention in nature (Rick Searle) -- No Ghost in the Machine (Alan M. Kadin) -- The Man in a Tailcoat  (Tommaso Bolognesi) -- The Tablet of the Metalaw (Cristinel Stoica) -- Wandering Towards a Goal: The Key Role of Biomolecules (George F. R. Ellis, Jonathan Kopel).